CIS-TOSYLATE

2

CIS-TOSYLATE
(Intermediate of Ketoconazole)
Chemical Name
cis-(2-(2,4-Dichlorophenyl)-2- [(1H – imidazole -1 – yI)-methyl]-1,3-dioxolan-4-yI) – methyl toluene sulphonate.
Molecular Formula
C21H20CI2N2O5S
Molecular Weight
483.12
Characteristics
White to Tan coloured powder : soluble in DMSO in methanol, in DMF; insoluble in water
Melting Range
122O to 126OC
Transmittance
Not less than 70.0% [10% soln in DMF @ 430nm]
Related impurities by Loss on drying
Not more than 0.5%
T.L.C.
Not more than 0.5%
Assay by titration
98.0% to 102%
Bulk Packing
Packed in double walled sealed HDPE/PVC bags enclosed in fiber / HDPE drums
Drums
25 / 50 Kgs.
Storage
Store in cool dry place